Restoration of tumor suppression in prostate cancer by targeting the E3 ligase E6AP
نویسندگان
چکیده
منابع مشابه
E6AP promotes prostate cancer by reducing p27 expression
Prostate cancer (PC) is the most common cancer in men. Elevated levels of E3 ligase, E6-Associated Protein (E6AP) were previously linked to PC, consistent with increased protein expression in a subset of PC patients. In cancers, irregular E3 ligase activity drives proteasomal degradation of tumor suppressor proteins. Accordingly, E3 ligase inhibitors define a rational therapy to restore tumor s...
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To identify novel oncogenic E3 ubiquitin ligases as anticancer targets, we screened an E3 ubiquitin ligase siRNA library containing siRNA pools against 555 individual E3s using the sulphorhodamine B assay in the MDA-MB-231 breast cancer cell line and the PC3 prostate cancer cell line. RNF126 was identified and validated as a candidate from this screening. Knockdown of RNF126 dramatically decrea...
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ژورنال
عنوان ژورنال: Oncogene
سال: 2016
ISSN: 0950-9232,1476-5594
DOI: 10.1038/onc.2016.159